Sedating antihistaminesĪs well as their H1 effect, sedating antihistamines can have alpha adrenergic, anticholinergic and serotonergic effects. In general, the lesser sedating antihistamines have less serious toxicity in overdose. H2 antagonists such as cimetidine and ranitidine are not covered by this guideline.Īntihistamines are divided into sedating and lesser sedating (previous called non-sedating) types. This guideline will only deal with H1 antagonists.
Consider investigating for common co-ingestions depending on the formulation, such as paracetamol levels.įor 24 hour advice, contact the Victorian Poisons Information Centre on 13 11 26 BackgroundĪntihistamines are commonly recommended for the treatment of allergic symptoms. Large overdoses of H1 Antihistamines are associated with cardiac arrhythmia and may require close monitoring and specific treatment. The majority of antihistamine poisonings will only require supportive care. Poisoning – acute guidelines for initial management Resuscitation Anticholinergic Poisoning Key points
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